RCE1 [The Human Chemical-Genetic Interaction Map Project]

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======= RCE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RCE1
  * **<color #00a2e8>Official Name</color>**: Ras converting CAAX endopeptidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9986|9986]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y256|Q9Y256]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RCE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RCE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605385|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068). {ECO:0000269|PubMed:10085068, ECO:0000269|PubMed:11038283, ECO:0000269|PubMed:19188362}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CAAX-box protein processing|
|CAAX-box protein maturation|
|endopeptidase activity|
|cysteine-type endopeptidase activity|
|metalloendopeptidase activity|
|integral component of endoplasmic reticulum membrane|
|protein processing|
|protein maturation|
|protein deubiquitination|
|protein modification by small protein removal|
|endoplasmic reticulum membrane|
|protein modification by small protein conjugation or removal|
|proteolysis|
|integral component of plasma membrane|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.62|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.35|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.21|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.18|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.12|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.08|
|[[:results:exp136|MS094 2μM R03 exp136]]|-2.01|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.93|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.93|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.83|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.83|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.82|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.73|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.73|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.73|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.73|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.71|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.7|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.3|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|4.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:shoc2|SHOC2]]|0.475|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.444|
|[[:human genes:r:rnf126|RNF126]]|0.426|
|[[:human genes:a:alg5|ALG5]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3370
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RCE1 Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>