RCE1

Entrez Summary: N/A
UniProt Summary: Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068). {ECO:0000269|PubMed:10085068, ECO:0000269|PubMed:11038283, ECO:0000269|PubMed:19188362}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ethanol 0.01 R05 exp234	-2.62
Rucaparib 6.5μM R08 exp520	-2.35
B02 10μM R08 exp453	-2.21
Lead acetate 2000μM R08 exp498 no dilution day6	-2.18
Cannabidiol 13μM R08 exp465	-2.12
AICAR 240μM R03 exp116	-2.08
MS094 2μM R03 exp136	-2.01
Asunaprenir 3μM R07 exp336	-1.93
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.93
Artemisinin 50μM R08 exp450	-1.83
Ibrutinib 10μM R08 exp442	-1.83
Rifampicin 10μM R00 exp32	-1.82
Dynasore 10μM R04 exp180	-1.73
Olaparib 4μM R08 exp512	-1.73
Parthenolide 2.5μM R05 exp238	-1.73
Talazoparib 0.006μM R06 exp299	-1.73
Thapsigargin 0.005μM R07 exp407	-1.71
Sulforaphane 9μM R08 exp525	-1.7
BI-6727 0.0125μM R03 exp97	2.3
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	4.85

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CAAX-box protein processing
CAAX-box protein maturation
endopeptidase activity
cysteine-type endopeptidase activity
metalloendopeptidase activity
integral component of endoplasmic reticulum membrane
protein processing
protein maturation
protein deubiquitination
protein modification by small protein removal
endoplasmic reticulum membrane
protein modification by small protein conjugation or removal
proteolysis
integral component of plasma membrane
membrane
gene expression