RDH13 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RDH13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RDH13
  * **<color #00a2e8>Official Name</color>**: retinol dehydrogenase 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=112724|112724]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NBN7|Q8NBN7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RDH13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RDH13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Does not exhibit retinol dehydrogenase (RDH) activity in vitro.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|adh short|
|KR|
|Epimerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to high light intensity|
|NADP-retinol dehydrogenase activity|
|response to light intensity|
|retinal metabolic process|
|retina layer formation|
|eye photoreceptor cell development|
|retinol metabolic process|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|retina morphogenesis in camera-type eye|
|cellular aldehyde metabolic process|
|photoreceptor cell differentiation|
|neural retina development|
|primary alcohol metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|camera-type eye morphogenesis|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|isoprenoid metabolic process|
|retina development in camera-type eye|
|eye morphogenesis|
|hormone metabolic process|
|sensory organ morphogenesis|
|response to light stimulus|
|camera-type eye development|
|alcohol metabolic process|
|eye development|
|visual system development|
|sensory system development|
|mitochondrial inner membrane|
|response to radiation|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|sensory organ development|
|neuron development|
|anatomical structure formation involved in morphogenesis|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|oxidation-reduction process|
|neuron differentiation|
|response to abiotic stimulus|
|lipid metabolic process|
|generation of neurons|
|neurogenesis|
|cell development|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6939
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RDH13 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>