RDH13

Entrez Summary: This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009].
UniProt Summary: Does not exhibit retinol dehydrogenase (RDH) activity in vitro.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to high light intensity
NADP-retinol dehydrogenase activity
response to light intensity
retinal metabolic process
retina layer formation
eye photoreceptor cell development
retinol metabolic process
eye photoreceptor cell differentiation
photoreceptor cell development
retina morphogenesis in camera-type eye
cellular aldehyde metabolic process
photoreceptor cell differentiation
neural retina development
primary alcohol metabolic process
retinoid metabolic process
diterpenoid metabolic process
camera-type eye morphogenesis
terpenoid metabolic process
cellular hormone metabolic process
isoprenoid metabolic process
retina development in camera-type eye
eye morphogenesis
hormone metabolic process
sensory organ morphogenesis
response to light stimulus
camera-type eye development
alcohol metabolic process
eye development
visual system development
sensory system development
mitochondrial inner membrane
response to radiation
organic hydroxy compound metabolic process
regulation of hormone levels
sensory organ development
neuron development
anatomical structure formation involved in morphogenesis
cellular lipid metabolic process
animal organ morphogenesis
oxidation-reduction process