RDH14

Entrez Summary: N/A
UniProt Summary: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected. {ECO:0000269|PubMed:12226107}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

steroid dehydrogenase activity
NADP-retinol dehydrogenase activity
retinol metabolic process
primary alcohol metabolic process
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
osteoblast differentiation
isoprenoid metabolic process
hormone metabolic process
ossification
lysosomal membrane
alcohol metabolic process
organic hydroxy compound metabolic process
regulation of hormone levels
endoplasmic reticulum membrane
cellular lipid metabolic process
oxidation-reduction process
endoplasmic reticulum
lipid metabolic process
small molecule metabolic process
membrane