RDH16

Entrez Summary: N/A
UniProt Summary: Oxidoreductase with a preference for NAD. Oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:12534290, ECO:0000269|PubMed:9677409}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

androstan-3-alpha,17-beta-diol dehydrogenase activity
androsterone dehydrogenase activity
retinol dehydrogenase activity
retinol metabolic process
electron transfer activity
primary alcohol metabolic process
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
isoprenoid metabolic process
electron transport chain
hormone metabolic process
steroid metabolic process
alcohol metabolic process
generation of precursor metabolites and energy
organic hydroxy compound metabolic process
regulation of hormone levels
intracellular membrane-bounded organelle
protein homodimerization activity
endoplasmic reticulum membrane
cellular lipid metabolic process
oxidation-reduction process
lipid metabolic process
small molecule metabolic process