RECK

Entrez Summary: N/A
UniProt Summary: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-6727 0.04μM R03 exp98	-1.77
VHL-ligand-1 20μM R07 exp421	2.06

coreceptor activity involved in canonical Wnt signaling pathway
negative regulation of metalloendopeptidase activity
regulation of establishment of blood-brain barrier
negative regulation of metallopeptidase activity
regulation of metalloendopeptidase activity
blood vessel maturation
Wnt signalosome
regulation of metallopeptidase activity
metalloendopeptidase inhibitor activity
embryonic forelimb morphogenesis
endopeptidase inhibitor activity
Wnt-protein binding
embryo implantation
forelimb morphogenesis
sprouting angiogenesis
canonical Wnt signaling pathway
serine-type endopeptidase inhibitor activity
anchored component of membrane
embryonic limb morphogenesis
embryonic appendage morphogenesis
anatomical structure maturation
positive regulation of canonical Wnt signaling pathway
limb morphogenesis
appendage morphogenesis
positive regulation of Wnt signaling pathway
appendage development
female pregnancy
limb development
multi-multicellular organism process
developmental maturation
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of cell migration
negative regulation of cell motility
regulation of canonical Wnt signaling pathway
regulation of angiogenesis
negative regulation of cellular component movement
angiogenesis
regulation of vasculature development
negative regulation of locomotion