RECQL

Entrez Summary: N/A
UniProt Summary: DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. {ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:7961977, ECO:0000269|PubMed:8056767}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Helicase C
DEAD

four-way junction helicase activity
annealing helicase activity
DNA strand renaturation
DNA unwinding involved in DNA replication
3-5 DNA helicase activity
DNA helicase activity
double-strand break repair via homologous recombination
recombinational repair
DNA duplex unwinding
DNA geometric change
DNA-dependent DNA replication
chromosome
double-strand break repair
DNA replication
DNA recombination
DNA conformation change
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
chromosome organization
DNA binding
ATP binding
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane