REG3A

Gene Information

Official Symbol: REG3A
Official Name: regenerating family member 3 alpha
Aliases and Previous Symbols: N/A
Entrez ID: 5068
UniProt: Q06141
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014].
UniProt Summary: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. {ECO:0000269|PubMed:16931762}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9604
Expression level (log2 read counts): -7.68

Expression Distribution

cell wall disruption in other organism
negative regulation of keratinocyte differentiation
oligosaccharide binding
positive regulation of keratinocyte proliferation
negative regulation of epidermal cell differentiation
peptidoglycan binding
negative regulation of epidermis development
regulation of keratinocyte proliferation
acute-phase response
negative regulation of epithelial cell differentiation
regulation of keratinocyte differentiation
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
positive regulation of wound healing
regulation of epidermal cell differentiation
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of response to wounding
acute inflammatory response
regulation of epidermis development
antimicrobial humoral response
transmembrane signaling receptor activity
regulation of wound healing
regulation of epithelial cell differentiation
modification of morphology or physiology of other organism
regulation of response to wounding
carbohydrate binding
positive regulation of epithelial cell proliferation
cell-cell adhesion via plasma-membrane adhesion molecules
regulation of epithelial cell proliferation
humoral immune response
response to peptide hormone
response to peptide
inflammatory response
cell-cell adhesion
negative regulation of cell differentiation
interspecies interaction between organisms
response to hormone
positive regulation of cell population proliferation
cell adhesion
biological adhesion
negative regulation of developmental process