REG3G [The Human Chemical-Genetic Interaction Map Project]

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======= REG3G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: REG3G
  * **<color #00a2e8>Official Name</color>**: regenerating family member 3 gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=130120|130120]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UW15|Q6UW15]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=REG3G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20REG3G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609933|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury. {ECO:0000269|PubMed:19095652}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell wall disruption in other organism|
|cytolysis in other organism|
|negative regulation of keratinocyte differentiation|
|oligosaccharide binding|
|positive regulation of keratinocyte proliferation|
|negative regulation of epidermal cell differentiation|
|peptidoglycan binding|
|negative regulation of epidermis development|
|multi-organism cellular process|
|cytolysis|
|MyD88-dependent toll-like receptor signaling pathway|
|regulation of keratinocyte proliferation|
|acute-phase response|
|regulation of keratinocyte differentiation|
|negative regulation of epithelial cell differentiation|
|killing of cells of other organism|
|disruption of cells of other organism|
|positive regulation of wound healing|
|regulation of epidermal cell differentiation|
|positive regulation of response to wounding|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|acute inflammatory response|
|regulation of epidermis development|
|cell killing|
|defense response to Gram-positive bacterium|
|toll-like receptor signaling pathway|
|antimicrobial humoral response|
|pattern recognition receptor signaling pathway|
|transmembrane signaling receptor activity|
|regulation of wound healing|
|regulation of epithelial cell differentiation|
|modification of morphology or physiology of other organism|
|regulation of response to wounding|
|positive regulation of epithelial cell proliferation|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|defense response to bacterium|
|regulation of epithelial cell proliferation|
|positive regulation of innate immune response|
|humoral immune response|
|positive regulation of response to biotic stimulus|
|response to peptide hormone|
|regulation of innate immune response|
|response to peptide|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|response to bacterium|
|negative regulation of cell differentiation|
|regulation of defense response|
|regulation of multi-organism process|
|interspecies interaction between organisms|
|positive regulation of immune response|
|response to hormone|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|defense response to other organism|
|response to organonitrogen compound|
|response to nitrogen compound|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell differentiation|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.94|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.72|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.476|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17998
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='REG3G Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>