REG3G

Gene Information

Official Symbol: REG3G
Official Name: regenerating family member 3 gamma
Aliases and Previous Symbols: N/A
Entrez ID: 130120
UniProt: Q6UW15
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury. {ECO:0000269|PubMed:19095652}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17998
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Hippuristanol 0.12μM R08 exp488	-1.94
Ethanol 0.003 R08 exp437	1.72
Momordin-Ic 10μM R08 exp506	1.86

cell wall disruption in other organism
cytolysis in other organism
negative regulation of keratinocyte differentiation
oligosaccharide binding
positive regulation of keratinocyte proliferation
negative regulation of epidermal cell differentiation
peptidoglycan binding
negative regulation of epidermis development
multi-organism cellular process
cytolysis
MyD88-dependent toll-like receptor signaling pathway
regulation of keratinocyte proliferation
acute-phase response
regulation of keratinocyte differentiation
negative regulation of epithelial cell differentiation
killing of cells of other organism
disruption of cells of other organism
positive regulation of wound healing
regulation of epidermal cell differentiation
positive regulation of response to wounding
antimicrobial humoral immune response mediated by antimicrobial peptide
acute inflammatory response
regulation of epidermis development
cell killing
defense response to Gram-positive bacterium
toll-like receptor signaling pathway
antimicrobial humoral response
pattern recognition receptor signaling pathway
transmembrane signaling receptor activity
regulation of wound healing
regulation of epithelial cell differentiation
modification of morphology or physiology of other organism
regulation of response to wounding
positive regulation of epithelial cell proliferation
innate immune response-activating signal transduction
activation of innate immune response
defense response to bacterium
regulation of epithelial cell proliferation
positive regulation of innate immune response
humoral immune response