RERE

Entrez Summary: This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebellar Purkinje cell layer maturation
cerebellum maturation
cerebellar cortex maturation
radial glia guided migration of Purkinje cell
branching morphogenesis of a nerve
cerebellar granule cell precursor proliferation
cell proliferation in external granule layer
hindbrain maturation
cell proliferation in hindbrain
central nervous system maturation
hindbrain radial glia guided cell migration
cell migration in hindbrain
cerebellar Purkinje cell layer development
histone deacetylase complex
cerebellar cortex development
dendrite morphogenesis
RNA polymerase II transcription factor binding
neural precursor cell proliferation
cerebellum development
dendrite development
metencephalon development
anatomical structure maturation
hindbrain development
chromatin remodeling
morphogenesis of a branching structure
developmental maturation
transcription corepressor activity
transcription coactivator activity
chromatin binding
sequence-specific DNA binding
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
cell population proliferation
cell morphogenesis involved in differentiation
neuron projection development
chromatin organization
cell morphogenesis