REV3L [The Human Chemical-Genetic Interaction Map Project]

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======= REV3L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: REV3L
  * **<color #00a2e8>Official Name</color>**: REV3 like, DNA directed polymerase zeta catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5980|5980]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60673|O60673]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=REV3L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20REV3L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602776|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol B|
|DNA pol B exo1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|zeta DNA polymerase complex|
|3-5 exonuclease activity|
|error-prone translesion synthesis|
|DNA-directed DNA polymerase activity|
|4 iron, 4 sulfur cluster binding|
|translesion synthesis|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|nucleotide binding|
|double-strand break repair via homologous recombination|
|recombinational repair|
|DNA biosynthetic process|
|DNA-dependent DNA replication|
|double-strand break repair|
|DNA replication|
|DNA recombination|
|nucleic acid phosphodiester bond hydrolysis|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|nucleolus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.86|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.82|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.439|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 57/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|4/28|
|bone|1/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|2/20|
|lung|7/75|
|lymphocyte|0/16|
|ovary|4/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1628
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='REV3L Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>