REV3L
Gene Information
- Official Symbol: REV3L
- Official Name: REV3 like, DNA directed polymerase zeta catalytic subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 5980
- UniProt: O60673
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017].
- UniProt Summary: Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1628
- Expression level (log2 read counts): 7.68
REV3L Expression in NALM6 Cells: 7.68
