RFNG

Entrez Summary: N/A
UniProt Summary: Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. {ECO:0000250|UniProtKB:O09009, ECO:0000250|UniProtKB:O12972, ECO:0000250|UniProtKB:Q9R1U9}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
protein O-linked fucosylation
fucosylation
acetylglucosaminyltransferase activity
positive regulation of Notch signaling pathway
integral component of Golgi membrane
positive regulation of protein binding
regulation of Notch signaling pathway
protein O-linked glycosylation
positive regulation of binding
regulation of protein binding
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
regulation of binding
glycoprotein metabolic process
pattern specification process
carbohydrate derivative biosynthetic process
molecular function
animal organ morphogenesis
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
positive regulation of signal transduction
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of molecular function
positive regulation of cell communication
positive regulation of signaling
extracellular region