RFTN1 [The Human Chemical-Genetic Interaction Map Project]

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======= RFTN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFTN1
  * **<color #00a2e8>Official Name</color>**: raftlin, lipid raft linker 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23180|23180]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14699|Q14699]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFTN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFTN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor- mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of growth rate|
|T cell antigen processing and presentation|
|interleukin-17 production|
|dsRNA transport|
|protein transport into membrane raft|
|regulation of growth rate|
|protein localization to membrane raft|
|protein transport within lipid bilayer|
|toll-like receptor 3 signaling pathway|
|membrane raft assembly|
|membrane raft organization|
|membrane assembly|
|membrane biogenesis|
|T cell mediated immunity|
|response to exogenous dsRNA|
|response to dsRNA|
|double-stranded RNA binding|
|localization within membrane|
|toll-like receptor signaling pathway|
|B cell receptor signaling pathway|
|pattern recognition receptor signaling pathway|
|cytokine production|
|T cell receptor signaling pathway|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|antigen processing and presentation|
|membrane raft|
|innate immune response-activating signal transduction|
|nucleobase-containing compound transport|
|early endosome|
|activation of innate immune response|
|positive regulation of growth|
|establishment of protein localization to membrane|
|lymphocyte mediated immunity|
|endosome|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|antigen receptor-mediated signaling pathway|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|protein-containing complex|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|adaptive immune response|
|activation of immune response|
|regulation of growth|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|membrane organization|
|positive regulation of immune response|
|response to organic cyclic compound|
|intracellular protein transport|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8596
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFTN1 Expression in NALM6 Cells: 4.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>