RFTN1

Entrez Summary: N/A
UniProt Summary: Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor- mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of growth rate
T cell antigen processing and presentation
interleukin-17 production
dsRNA transport
protein transport into membrane raft
regulation of growth rate
protein localization to membrane raft
protein transport within lipid bilayer
toll-like receptor 3 signaling pathway
membrane raft assembly
membrane raft organization
membrane assembly
membrane biogenesis
T cell mediated immunity
response to exogenous dsRNA
response to dsRNA
double-stranded RNA binding
localization within membrane
toll-like receptor signaling pathway
B cell receptor signaling pathway
pattern recognition receptor signaling pathway
cytokine production
T cell receptor signaling pathway
RNA transport
nucleic acid transport
establishment of RNA localization
RNA localization
antigen processing and presentation
membrane raft
innate immune response-activating signal transduction
nucleobase-containing compound transport
early endosome
activation of innate immune response
positive regulation of growth
establishment of protein localization to membrane
lymphocyte mediated immunity
endosome
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
antigen receptor-mediated signaling pathway
positive regulation of innate immune response