RFX2

Entrez Summary: N/A
UniProt Summary: Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity). {ECO:0000250|UniProtKB:P48379, ECO:0000269|PubMed:10330134}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RFX1 trans act
RFX DNA binding

acrosome assembly
secretory granule organization
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
cellular component assembly involved in morphogenesis
spermatid development
spermatid differentiation
germ cell development
vesicle organization
cilium assembly
cellular process involved in reproduction in multicellular organism
cilium organization
endomembrane system organization
plasma membrane bounded cell projection assembly
cell projection assembly
RNA polymerase II proximal promoter sequence-specific DNA binding
spermatogenesis
male gamete generation
developmental process involved in reproduction
DNA-binding transcription factor activity
gamete generation
organelle assembly
cellular component morphogenesis
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
anatomical structure formation involved in morphogenesis
multi-organism reproductive process
cellular response to cytokine stimulus
response to cytokine
plasma membrane bounded cell projection organization
cell projection organization
positive regulation of transcription by RNA polymerase II
reproductive process
reproduction
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process