RGS9

Gene Information

Official Symbol: RGS9
Official Name: regulator of G protein signaling 9
Aliases and Previous Symbols: N/A
Entrez ID: 8787
UniProt: O75916
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
UniProt Summary: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5139
Expression level (log2 read counts): 2.62

Expression Distribution

G-gamma
RGS
DEP

regulation of calcium ion export across plasma membrane
positive regulation of NMDA glutamate receptor activity
positive regulation of glutamate receptor signaling pathway
postsynaptic density membrane
response to amphetamine
positive regulation of signaling receptor activity
dopamine receptor signaling pathway
regulation of NMDA receptor activity
response to amine
response to bronchodilator
regulation of glutamate receptor signaling pathway
positive regulation of cation channel activity
regulation of neurotransmitter receptor activity
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
positive regulation of ion transmembrane transporter activity
response to monoamine
response to catecholamine
positive regulation of transporter activity
cellular response to ammonium ion
response to estradiol
positive regulation of cation transmembrane transport
regulation of G protein-coupled receptor signaling pathway
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
regulation of cation channel activity
regulation of signaling receptor activity
response to ammonium ion
positive regulation of transmembrane transport
visual perception
sensory perception of light stimulus
protein folding
regulation of calcium ion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity