RHO [The Human Chemical-Genetic Interaction Map Project]

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======= RHO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHO
  * **<color #00a2e8>Official Name</color>**: rhodopsin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6010|6010]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08100|P08100]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G- protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343). {ECO:0000269|PubMed:12566452, ECO:0000269|PubMed:2215617, ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425, ECO:0000269|PubMed:7846071, ECO:0000269|PubMed:8107847, ECO:0000305|PubMed:28524165}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srw|
|7TM GPCR Srsx|
|7tm 1|
|Rhodopsin N|
|7TM GPCR Srv|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|light absorption|
|absorption of visible light|
|photoreceptor inner segment membrane|
|11-cis retinal binding|
|rhodopsin mediated signaling pathway|
|protein-chromophore linkage|
|G protein-coupled photoreceptor activity|
|photoreceptor outer segment membrane|
|phototransduction, visible light|
|Golgi-associated vesicle membrane|
|photoreceptor disc membrane|
|regulation of rhodopsin mediated signaling pathway|
|photoreceptor cell maintenance|
|phototransduction|
|detection of visible light|
|photoreceptor inner segment|
|ciliary membrane|
|photoreceptor outer segment|
|detection of light stimulus|
|retina homeostasis|
|retinoid metabolic process|
|diterpenoid metabolic process|
|cellular response to light stimulus|
|detection of external stimulus|
|terpenoid metabolic process|
|detection of abiotic stimulus|
|isoprenoid metabolic process|
|retina development in camera-type eye|
|regulation of G protein-coupled receptor signaling pathway|
|cell-cell junction|
|cellular response to radiation|
|tissue homeostasis|
|visual perception|
|sensory perception of light stimulus|
|response to light stimulus|
|camera-type eye development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|eye development|
|visual system development|
|sensory system development|
|response to radiation|
|sensory organ development|
|Golgi membrane|
|detection of stimulus|
|G protein-coupled receptor activity|
|cellular lipid metabolic process|
|sensory perception|
|protein phosphorylation|
|Golgi apparatus|
|regulation of response to external stimulus|
|response to abiotic stimulus|
|lipid metabolic process|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|homeostatic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6031
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHO Expression in NALM6 Cells: -1.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>