RHO

Entrez Summary: The protein encoded by this gene is found in rod cells in the back of the eye and is essential for vision in low-light conditions. The encoded protein binds to 11-cis retinal and is activated when light hits the retinal molecule. Defects in this gene are a cause of congenital stationary night blindness. [provided by RefSeq, Aug 2017].
UniProt Summary: Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G- protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343). {ECO:0000269|PubMed:12566452, ECO:0000269|PubMed:2215617, ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425, ECO:0000269|PubMed:7846071, ECO:0000269|PubMed:8107847, ECO:0000305|PubMed:28524165}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

light absorption
absorption of visible light
photoreceptor inner segment membrane
11-cis retinal binding
rhodopsin mediated signaling pathway
protein-chromophore linkage
G protein-coupled photoreceptor activity
photoreceptor outer segment membrane
phototransduction, visible light
Golgi-associated vesicle membrane
photoreceptor disc membrane
regulation of rhodopsin mediated signaling pathway
photoreceptor cell maintenance
phototransduction
detection of visible light
photoreceptor inner segment
ciliary membrane
photoreceptor outer segment
detection of light stimulus
retina homeostasis
retinoid metabolic process
diterpenoid metabolic process
cellular response to light stimulus
detection of external stimulus
terpenoid metabolic process
detection of abiotic stimulus
isoprenoid metabolic process
retina development in camera-type eye
regulation of G protein-coupled receptor signaling pathway
cell-cell junction
cellular response to radiation
tissue homeostasis
visual perception
sensory perception of light stimulus
response to light stimulus
camera-type eye development
cellular response to abiotic stimulus
cellular response to environmental stimulus
multicellular organismal homeostasis
anatomical structure homeostasis