RHOBTB3 [The Human Chemical-Genetic Interaction Map Project]

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======= RHOBTB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHOBTB3
  * **<color #00a2e8>Official Name</color>**: Rho related BTB domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22836|22836]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94955|O94955]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHOBTB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHOBTB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269|PubMed:19490898}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rho protein signal transduction|
|retrograde transport, endosome to Golgi|
|trans-Golgi network membrane|
|cell projection|
|male gonad development|
|development of primary male sexual characteristics|
|cell cortex|
|cytosolic transport|
|Rab GTPase binding|
|regulation of cell shape|
|male sex differentiation|
|establishment or maintenance of cell polarity|
|gonad development|
|development of primary sexual characteristics|
|endosomal transport|
|ATPase activity|
|actin filament organization|
|Ras protein signal transduction|
|sex differentiation|
|small GTPase mediated signal transduction|
|GTPase activity|
|regulation of actin cytoskeleton organization|
|regulation of actin filament-based process|
|GTP binding|
|reproductive structure development|
|reproductive system development|
|supramolecular fiber organization|
|protein kinase binding|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of cytoskeleton organization|
|actin filament-based process|
|developmental process involved in reproduction|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|ATP binding|
|intracellular transport|
|intracellular signal transduction|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.84|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15857
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHOBTB3 Expression in NALM6 Cells: 3.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>