RHOBTB3

Entrez Summary: N/A
UniProt Summary: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269|PubMed:19490898}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nicotinamide 2000μM R01 exp50	-1.84
3-Bromopyruvate 7μM R04 exp175	1.91

Rho protein signal transduction
retrograde transport, endosome to Golgi
trans-Golgi network membrane
cell projection
male gonad development
development of primary male sexual characteristics
cell cortex
cytosolic transport
Rab GTPase binding
regulation of cell shape
male sex differentiation
establishment or maintenance of cell polarity
gonad development
development of primary sexual characteristics
endosomal transport
ATPase activity
actin filament organization
Ras protein signal transduction
sex differentiation
small GTPase mediated signal transduction
GTPase activity
regulation of actin cytoskeleton organization
regulation of actin filament-based process
GTP binding
reproductive structure development
reproductive system development
supramolecular fiber organization
protein kinase binding
regulation of cell morphogenesis
actin cytoskeleton organization
regulation of cytoskeleton organization
actin filament-based process
developmental process involved in reproduction
regulation of anatomical structure morphogenesis
cytoskeleton organization
regulation of organelle organization
reproductive process
reproduction
ATP binding
intracellular transport