RHOU

Entrez Summary: N/A
UniProt Summary: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:21834987}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ras
Miro

Cdc42 protein signal transduction
Rac protein signal transduction
podosome
positive regulation of protein targeting to mitochondrion
regulation of protein targeting to mitochondrion
positive regulation of establishment of protein localization to mitochondrion
regulation of establishment of protein localization to mitochondrion
Rho protein signal transduction
regulation of protein targeting
cell projection
positive regulation of mitochondrion organization
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
cell cortex
regulation of cell shape
positive regulation of intracellular protein transport
regulation of mitochondrion organization
establishment or maintenance of cell polarity
positive regulation of intracellular transport
regulation of intracellular protein transport
actin filament organization
Ras protein signal transduction
mitotic cell cycle phase transition
cell cycle phase transition
small GTPase mediated signal transduction
positive regulation of cellular protein localization
GTPase activity
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of intracellular transport
regulation of actin filament-based process
GTP binding
focal adhesion
positive regulation of protein transport
supramolecular fiber organization
cell projection assembly
positive regulation of establishment of protein localization
protein kinase binding
regulation of cell morphogenesis
actin cytoskeleton organization