RHOV

Entrez Summary: N/A
UniProt Summary: Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway. {ECO:0000250|UniProtKB:Q9Z1Y0}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lapatinib 5μM R01 exp47	1.76
ML-792 0.2μM R08 exp505	1.78

Ras
Miro

Cdc42 protein signal transduction
Rho protein signal transduction
cell projection
cell cortex
regulation of cell shape
establishment or maintenance of cell polarity
endosome membrane
actin filament organization
Ras protein signal transduction
small GTPase mediated signal transduction
GTPase activity
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of actin filament-based process
GTP binding
supramolecular fiber organization
cell projection assembly
protein kinase binding
regulation of cell morphogenesis
actin cytoskeleton organization
regulation of cytoskeleton organization
endocytosis
actin filament-based process
import into cell
regulation of anatomical structure morphogenesis
cytoskeleton organization
cell projection organization
regulation of organelle organization
intracellular signal transduction
regulation of intracellular signal transduction
vesicle-mediated transport