RIMBP3

Entrez Summary: N/A
UniProt Summary: Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male fertility. {ECO:0000250|UniProtKB:Q3V0F0}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

benzodiazepine receptor binding
manchette
neuromuscular synaptic transmission
spermatid development
spermatid differentiation
fertilization
germ cell development
cellular process involved in reproduction in multicellular organism
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell-cell signaling
reproductive process
reproduction
cell development