RING1 [The Human Chemical-Genetic Interaction Map Project]

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======= RING1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RING1
  * **<color #00a2e8>Official Name</color>**: ring finger protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6015|6015]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06587|Q06587]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RING1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RING1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602045|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sex chromatin|
|ubiquitin-protein transferase activator activity|
|PRC1 complex|
|histone H2A monoubiquitination|
|histone H2A ubiquitination|
|PcG protein complex|
|histone monoubiquitination|
|negative regulation of G0 to G1 transition|
|histone ubiquitination|
|regulation of G0 to G1 transition|
|transferase activity|
|protein monoubiquitination|
|ubiquitin ligase complex|
|camera-type eye morphogenesis|
|eye morphogenesis|
|anterior/posterior pattern specification|
|ubiquitin protein ligase activity|
|sensory organ morphogenesis|
|camera-type eye development|
|negative regulation of cell cycle process|
|regionalization|
|eye development|
|visual system development|
|histone modification|
|sensory system development|
|covalent chromatin modification|
|chromatin binding|
|nuclear speck|
|pattern specification process|
|sensory organ development|
|negative regulation of cell cycle|
|protein ubiquitination|
|chromatin organization|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|animal organ morphogenesis|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.68|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-3.57|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.74|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.44|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.37|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.32|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.24|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.1|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.07|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.03|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.03|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.01|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.98|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.93|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.93|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.93|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.92|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.88|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.87|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.86|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.85|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.77|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.77|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.76|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.73|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.73|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.77|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.84|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.86|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.99|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.15|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.31|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pcgf1|PCGF1]]|0.678|
|[[:human genes:u:ube2e1|UBE2E1]]|0.565|
|[[:human genes:b:bcor|BCOR]]|0.543|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.503|
|[[:human genes:p:pou2af1|POU2AF1]]|0.483|
|[[:human genes:g:glyr1|GLYR1]]|0.454|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.435|
|[[:human genes:c:cdk8|CDK8]]|0.428|
|[[:human genes:i:ikzf2|IKZF2]]|0.423|
|[[:human genes:p:poldip2|POLDIP2]]|0.418|
|[[:human genes:o:otub1|OTUB1]]|0.416|
|[[:human genes:k:kdm6a|KDM6A]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17961
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RING1 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>