RING1

Entrez Summary: N/A
UniProt Summary: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-3.68
LY2090314 0.003μM R08 exp500 no dilution day6	-3.57
Aphidicolin 0.4μM R08 exp440	-2.74
UMK57 1μM R01 exp59	-2.44
UM0129480 7μM R02 exp85	-2.37
Resveratrol 16μM R03 exp147	-2.32
UM131593 0.2μM R03 exp106	-2.24
SNS-032 25μM R07 exp401	-2.1
Rotenone 2μM R00 exp33	-2.07
Fluvastatin 2.2μM R06 exp282	-2.03
Vincristine 0.0005μM R04 exp190	-2.03
Wortmannin 5μM R00 exp38	-2.01
Thimerosal 0.85μM R08 exp529	-1.98
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.93
Artemisinin 50μM R08 exp450	-1.93
Cerivastatin 0.15μM R05 exp226	-1.93
DABN 20μM R00 exp17	-1.92
Monensin 0.3μM R08 exp507	-1.88
Hydroxyurea 100μM R07 exp329	-1.87
Vinblastine 0.002μM R01 exp60	-1.86
3-Bromopyruvate 7μM R04 exp175	-1.85
Pterostilbene 16μM R02 exp78	-1.77
RO-3307 4.7μM R02 exp80	-1.77
RK-33 8μM R08 exp518	-1.76
Nocodazole 0.1μM R03 exp94	-1.73
Disulfiram 4.3μM R06 exp281	1.73
Thapsigargin 0.005μM R07 exp407	1.77
Calcium Ionophore 0.4μM R07 exp342	1.84
All-trans-Retinoic-Acid 8μM R07 exp333	1.86
THZ531 0.11μM R07 exp409	1.99
Pomalidomide 20μM R07 exp391	2.15
Dimethyloxaloylglycine 100μM R05 exp229	2.31
Vemurafenib 6.6μM R08 exp434	2.48

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sex chromatin
ubiquitin-protein transferase activator activity
PRC1 complex
histone H2A monoubiquitination
histone H2A ubiquitination
PcG protein complex
histone monoubiquitination
negative regulation of G0 to G1 transition
histone ubiquitination
regulation of G0 to G1 transition
transferase activity
protein monoubiquitination
ubiquitin ligase complex
camera-type eye morphogenesis
eye morphogenesis
anterior/posterior pattern specification
ubiquitin protein ligase activity
sensory organ morphogenesis
camera-type eye development
negative regulation of cell cycle process
regionalization
eye development
visual system development
histone modification
sensory system development
covalent chromatin modification
chromatin binding
nuclear speck
pattern specification process
sensory organ development
negative regulation of cell cycle
protein ubiquitination
chromatin organization
regulation of cell cycle process
protein modification by small protein conjugation
animal organ morphogenesis
protein modification by small protein conjugation or removal
chromosome organization
regulation of cell cycle
negative regulation of transcription, DNA-templated