RIOK2 [The Human Chemical-Genetic Interaction Map Project]

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======= RIOK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIOK2
  * **<color #00a2e8>Official Name</color>**: RIO kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55781|55781]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVS4|Q9BVS4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIOK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIOK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617754|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RIO1|
|Kdo|
|Rio2 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of ribosomal subunit export from nucleus|
|positive regulation of ribosomal subunit export from nucleus|
|positive regulation of ribonucleoprotein complex localization|
|regulation of ribosomal small subunit export from nucleus|
|positive regulation of ribosomal small subunit export from nucleus|
|regulation of ribonucleoprotein complex localization|
|positive regulation of RNA export from nucleus|
|positive regulation of rRNA processing|
|positive regulation of ribosome biogenesis|
|positive regulation of nucleobase-containing compound transport|
|regulation of rRNA processing|
|preribosome, small subunit precursor|
|regulation of ribosome biogenesis|
|regulation of RNA export from nucleus|
|regulation of nucleobase-containing compound transport|
|positive regulation of protein export from nucleus|
|regulation of protein export from nucleus|
|maturation of SSU-rRNA|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|positive regulation of nucleocytoplasmic transport|
|regulation of mitotic sister chromatid segregation|
|ribosomal small subunit biogenesis|
|regulation of sister chromatid segregation|
|regulation of chromosome segregation|
|regulation of nucleocytoplasmic transport|
|positive regulation of intracellular protein transport|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|protein autophosphorylation|
|positive regulation of intracellular transport|
|rRNA processing|
|rRNA metabolic process|
|regulation of intracellular protein transport|
|protein kinase activity|
|ribosome biogenesis|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of intracellular transport|
|protein serine/threonine kinase activity|
|ncRNA processing|
|regulation of mitotic cell cycle phase transition|
|positive regulation of protein transport|
|regulation of cell cycle phase transition|
|ribonucleoprotein complex biogenesis|
|positive regulation of establishment of protein localization|
|ncRNA metabolic process|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|regulation of mitotic cell cycle|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|RNA processing|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|positive regulation of transport|
|regulation of protein localization|
|regulation of cell cycle|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|ATP binding|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.79|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.7|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.75|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.77|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.78|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.79|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.8|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.82|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.98|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.99|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:orc1|ORC1]]|0.518|
|[[:human genes:t:tfip11|TFIP11]]|0.515|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.494|
|[[:human genes:r:rad51|RAD51]]|0.485|
|[[:human genes:t:ticrr|TICRR]]|0.48|
|[[:human genes:c:cdc6|CDC6]]|0.476|
|[[:human genes:p:psmb4|PSMB4]]|0.476|
|[[:human genes:v:vasn|VASN]]|0.474|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.471|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.47|
|[[:human genes:s:slc4a1|SLC4A1]]|0.467|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.465|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.465|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.465|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.465|
|[[:human genes:s:supt6h|SUPT6H]]|0.464|
|[[:human genes:r:rps5|RPS5]]|0.459|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.458|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.457|
|[[:human genes:n:narfl|NARFL]]|0.456|
|[[:human genes:c:chd4|CHD4]]|0.456|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.455|
|[[:human genes:r:rps2|RPS2]]|0.453|
|[[:human genes:c:copg1|COPG1]]|0.453|
|[[:human genes:p:prim1|PRIM1]]|0.452|
|[[:human genes:k:kctd17|KCTD17]]|0.448|
|[[:human genes:p:psma6|PSMA6]]|0.448|
|[[:human genes:c:cbwd3|CBWD3]]|0.448|
|[[:human genes:c:cope|COPE]]|0.445|
|[[:human genes:s:s1pr4|S1PR4]]|0.445|
|[[:human genes:c:cactin|CACTIN]]|0.443|
|[[:human genes:c:chaf1a|CHAF1A]]|0.44|
|[[:human genes:r:rps28|RPS28]]|0.44|
|[[:human genes:r:rpl35|RPL35]]|0.439|
|[[:human genes:p:polr2j3|POLR2J3]]|0.439|
|[[:human genes:c:cbwd5|CBWD5]]|0.437|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.437|
|[[:human genes:f:fbxw9|FBXW9]]|0.437|
|[[:human genes:s:smg1|SMG1]]|0.437|
|[[:human genes:d:ddx21|DDX21]]|0.436|
|[[:human genes:h:hivep3|HIVEP3]]|0.435|
|[[:human genes:c:ckap5|CKAP5]]|0.434|
|[[:human genes:n:nup160|NUP160]]|0.434|
|[[:human genes:n:nol10|NOL10]]|0.432|
|[[:human genes:v:vps54|VPS54]]|0.432|
|[[:human genes:p:pcf11|PCF11]]|0.431|
|[[:human genes:p:psmd3|PSMD3]]|0.43|
|[[:human genes:t:timeless|TIMELESS]]|0.43|
|[[:human genes:r:rpl34|RPL34]]|0.429|
|[[:human genes:n:npipb5|NPIPB5]]|0.428|
|[[:human genes:p:pole|POLE]]|0.427|
|[[:human genes:n:nbpf10|NBPF10]]|0.427|
|[[:human genes:r:rrp7a|RRP7A]]|0.427|
|[[:human genes:s:stil|STIL]]|0.427|
|[[:human genes:t:tceb3c|TCEB3C]]|0.427|
|[[:human genes:o:ogfr|OGFR]]|0.424|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.424|
|[[:human genes:a:aatf|AATF]]|0.424|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.423|
|[[:human genes:a:arcn1|ARCN1]]|0.422|
|[[:human genes:g:golga6a|GOLGA6A]]|0.422|
|[[:human genes:s:ssh2|SSH2]]|0.419|
|[[:human genes:k:krt78|KRT78]]|0.419|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.418|
|[[:human genes:r:rbm39|RBM39]]|0.416|
|[[:human genes:p:psmd2|PSMD2]]|0.416|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.416|
|[[:human genes:i:iscu|ISCU]]|0.416|
|[[:human genes:c:cdc45|CDC45]]|0.415|
|[[:human genes:m:mt1e|MT1E]]|0.415|
|[[:human genes:f:fcn2|FCN2]]|0.414|
|[[:human genes:t:twistnb|TWISTNB]]|0.413|
|[[:human genes:s:slc38a7|SLC38A7]]|0.413|
|[[:human genes:d:dido1|DIDO1]]|0.412|
|[[:human genes:s:sf3a3|SF3A3]]|0.412|
|[[:human genes:p:pwp2|PWP2]]|0.411|
|[[:human genes:a:ahctf1|AHCTF1]]|0.411|
|[[:human genes:r:rpl38|RPL38]]|0.411|
|[[:human genes:p:pola1|POLA1]]|0.41|
|[[:human genes:u:utp20|UTP20]]|0.409|
|[[:human genes:u:uqcrh|UQCRH]]|0.409|
|[[:human genes:p:psmb2|PSMB2]]|0.408|
|[[:human genes:c:c14orf93|C14orf93]]|0.408|
|[[:human genes:r:rps12|RPS12]]|0.408|
|[[:human genes:n:nupl1|NUPL1]]|0.408|
|[[:human genes:t:tspy1|TSPY1]]|0.408|
|[[:human genes:r:rps11|RPS11]]|0.407|
|[[:human genes:u:upf1|UPF1]]|0.407|
|[[:human genes:r:rilpl2|RILPL2]]|0.407|
|[[:human genes:r:rpl14|RPL14]]|0.406|
|[[:human genes:p:paf1|PAF1]]|0.405|
|[[:human genes:r:rrp15|RRP15]]|0.405|
|[[:human genes:c:cbwd6|CBWD6]]|0.404|
|[[:human genes:t:top1mt|TOP1MT]]|0.404|
|[[:human genes:c:chmp2a|CHMP2A]]|0.404|
|[[:human genes:p:plk4|PLK4]]|0.404|
|[[:human genes:h:hap1|HAP1]]|0.403|
|[[:human genes:c:casc5|CASC5]]|0.403|
|[[:human genes:t:terf1|TERF1]]|0.402|
|[[:human genes:c:cdca3|CDCA3]]|0.401|
|[[:human genes:m:myb|MYB]]|0.401|
|[[:human genes:p:psap|PSAP]]|0.4|
|[[:human genes:r:rbbp5|RBBP5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 414/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|21/28|
|bone|18/26|
|breast|18/33|
|central nervous system|30/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|11/21|
|liver|15/20|
|lung|51/75|
|lymphocyte|11/16|
|ovary|19/26|
|pancreas|11/24|
|peripheral nervous system|12/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|2/9|
|thyroid|2/2|
|upper aerodigestive|12/22|
|urinary tract|17/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 806
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIOK2 Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>