RIOK2

Gene Information

Official Symbol: RIOK2
Official Name: RIO kinase 2
Aliases and Previous Symbols: N/A
Entrez ID: 55781
UniProt: Q9BVS4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1.5μM R08 exp441	-1.79
UM0011500 5μM R05 exp245	1.7
Daidzin 10μM R06 exp280	1.75
L-74142 5μM R03 exp131	1.77
Myriocin 25μM R06 exp293	1.78
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.79
Celastrol 0.12μM R05 exp225	1.8
Alpha-Amanitin 0.5μM R00 exp5	1.82
Menadione 5μM R06 exp292	1.98
Hypoxia 5%O2 R04 exp191	1.99
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.03

Gene	Correlation
ORC1	0.518
TFIP11	0.515
TBC1D3G	0.494
RAD51	0.485
TICRR	0.48
CDC6	0.476
PSMB4	0.476
VASN	0.474
TBC1D3C	0.471
TBC1D3H	0.47
SLC4A1	0.467
TBC1D3K	0.465
TBC1D3L	0.465
TBC1D3I	0.465
TBC1D3E	0.465
SUPT6H	0.464
RPS5	0.459
TCEB3CL2	0.458
TBC1D3	0.457
NARFL	0.456
CHD4	0.456
TBC1D3F	0.455
RPS2	0.453
COPG1	0.453
PRIM1	0.452
KCTD17	0.448
PSMA6	0.448
CBWD3	0.448
COPE	0.445
S1PR4	0.445
CACTIN	0.443
CHAF1A	0.44
RPS28	0.44
RPL35	0.439
POLR2J3	0.439
CBWD5	0.437
DNTTIP2	0.437
FBXW9	0.437
SMG1	0.437
DDX21	0.436
HIVEP3	0.435
CKAP5	0.434
NUP160	0.434
NOL10	0.432
VPS54	0.432
PCF11	0.431
PSMD3	0.43
TIMELESS	0.43
RPL34	0.429
NPIPB5	0.428
POLE	0.427
NBPF10	0.427
RRP7A	0.427
STIL	0.427
TCEB3C	0.427
OGFR	0.424
RPS19BP1	0.424
AATF	0.424
TCEB3CL	0.423
ARCN1	0.422
GOLGA6A	0.422
SSH2	0.419
KRT78	0.419
ATP6V0C	0.418
RBM39	0.416
PSMD2	0.416
C1QTNF9B	0.416
ISCU	0.416
CDC45	0.415
MT1E	0.415
FCN2	0.414
TWISTNB	0.413
SLC38A7	0.413
DIDO1	0.412
SF3A3	0.412
PWP2	0.411
AHCTF1	0.411
RPL38	0.411
POLA1	0.41
UTP20	0.409
UQCRH	0.409
PSMB2	0.408
C14orf93	0.408
RPS12	0.408
NUPL1	0.408
TSPY1	0.408
RPS11	0.407
UPF1	0.407
RILPL2	0.407
RPL14	0.406
PAF1	0.405
RRP15	0.405
CBWD6	0.404
TOP1MT	0.404
CHMP2A	0.404
PLK4	0.404
HAP1	0.403
CASC5	0.403
TERF1	0.402
CDCA3	0.401
MYB	0.401
PSAP	0.4
RBBP5	0.4

Global Fraction of Cell Lines Where Essential: 414/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	13/28
blood	21/28
bone	18/26
breast	18/33
central nervous system	30/56
cervix	1/4
colorectal	7/17
esophagus	8/13
fibroblast	0/1
gastric	10/16
kidney	11/21
liver	15/20
lung	51/75
lymphocyte	11/16
ovary	19/26
pancreas	11/24
peripheral nervous system	12/16
plasma cell	8/15
prostate	0/1
skin	12/24
soft tissue	2/9
thyroid	2/2
upper aerodigestive	12/22
urinary tract	17/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 806
Expression level (log2 read counts): 5.73

Expression Distribution

RIO1
Kdo
Rio2 N

regulation of ribosomal subunit export from nucleus
positive regulation of ribosomal subunit export from nucleus
positive regulation of ribonucleoprotein complex localization
regulation of ribosomal small subunit export from nucleus
positive regulation of ribosomal small subunit export from nucleus
regulation of ribonucleoprotein complex localization
positive regulation of RNA export from nucleus
positive regulation of rRNA processing
positive regulation of ribosome biogenesis
positive regulation of nucleobase-containing compound transport
regulation of rRNA processing
preribosome, small subunit precursor
regulation of ribosome biogenesis
regulation of RNA export from nucleus
regulation of nucleobase-containing compound transport
positive regulation of protein export from nucleus
regulation of protein export from nucleus
maturation of SSU-rRNA
regulation of mitotic metaphase/anaphase transition
regulation of metaphase/anaphase transition of cell cycle
regulation of mitotic sister chromatid separation
regulation of chromosome separation
positive regulation of nucleocytoplasmic transport
regulation of mitotic sister chromatid segregation
ribosomal small subunit biogenesis
regulation of sister chromatid segregation
regulation of chromosome segregation
regulation of nucleocytoplasmic transport
positive regulation of intracellular protein transport
regulation of mitotic nuclear division
regulation of nuclear division
protein autophosphorylation
positive regulation of intracellular transport
rRNA processing
rRNA metabolic process
regulation of intracellular protein transport
protein kinase activity
ribosome biogenesis
positive regulation of cellular protein localization
regulation of chromosome organization