RNASE3

Entrez Summary: N/A
UniProt Summary: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. {ECO:0000269|PubMed:19450231, ECO:0000269|PubMed:2501794}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
POLR2J3	0.435
NBPF10	0.434

induction of bacterial agglutination
innate immune response in mucosa
ribonuclease activity
mucosal immune response
organ or tissue specific immune response
lipopolysaccharide binding
antibacterial humoral response
endonuclease activity
antimicrobial humoral immune response mediated by antimicrobial peptide
defense response to Gram-negative bacterium
azurophil granule lumen
defense response to Gram-positive bacterium
antimicrobial humoral response
RNA phosphodiester bond hydrolysis
nucleic acid binding
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
defense response to bacterium
humoral immune response
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
response to bacterium
regulated exocytosis
leukocyte mediated immunity
innate immune response
exocytosis