RNASE7

Entrez Summary: N/A
UniProt Summary: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768, ECO:0000269|PubMed:17150966}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

membrane disruption in other organism
peptidoglycan binding
ribonuclease activity
lipopolysaccharide binding
defense response to fungus
endonuclease activity
antibacterial humoral response
response to fungus
antimicrobial humoral immune response mediated by antimicrobial peptide
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
antimicrobial humoral response
modification of morphology or physiology of other organism
RNA phosphodiester bond hydrolysis
nucleic acid binding
nucleic acid phosphodiester bond hydrolysis
defense response to bacterium
humoral immune response
response to bacterium
innate immune response
interspecies interaction between organisms
defense response to other organism
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
extracellular space
RNA metabolic process
immune response
extracellular region