RNASEL

Gene Information

Official Symbol: RNASEL
Official Name: ribonuclease L
Aliases and Previous Symbols: N/A
Entrez ID: 6041
UniProt: Q05823
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008].
UniProt Summary: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:26263979}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4436
Expression level (log2 read counts): 5.49

Expression Distribution

Pkinase Tyr
Ribonuc 2-5A
Pkinase
Ank 2
Ank

endoribonuclease activity
ribonucleoprotein complex binding
regulation of type I interferon-mediated signaling pathway
rRNA binding
positive regulation of glucose import
positive regulation of glucose transmembrane transport
regulation of glucose import
negative regulation of viral genome replication
cellular response to type I interferon
type I interferon signaling pathway
response to type I interferon
regulation of glucose transmembrane transport
RNA phosphodiester bond hydrolysis, endonucleolytic
negative regulation of viral life cycle
regulation of viral genome replication
negative regulation of viral process
fat cell differentiation
nuclear matrix
regulation of viral life cycle
RNA phosphodiester bond hydrolysis
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
regulation of mRNA stability
regulation of RNA stability
defense response to virus
regulation of mRNA catabolic process
positive regulation of transmembrane transport
regulation of viral process
rRNA processing
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
rRNA metabolic process
protein kinase activity
response to virus
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
regulation of mRNA metabolic process
mitochondrial matrix
ncRNA processing
cellular component