RNF10

Gene Information

Official Symbol: RNF10
Official Name: ring finger protein 10
Aliases and Previous Symbols: N/A
Entrez ID: 9921
UniProt: Q8N5U6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination. {ECO:0000250|UniProtKB:Q5XI59}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4346
Expression level (log2 read counts): 6.7

Expression Distribution

negative regulation of Schwann cell proliferation
regulation of Schwann cell proliferation
negative regulation of glial cell proliferation
positive regulation of myelination
regulation of glial cell proliferation
negative regulation of gliogenesis
regulation of myelination
positive regulation of nervous system process
protein autoubiquitination
regulation of gliogenesis
regulation of nervous system process
transcription regulatory region DNA binding
ubiquitin-protein transferase activity
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
positive regulation of nervous system development
regulation of system process
negative regulation of cell population proliferation
protein ubiquitination
negative regulation of cell differentiation
protein modification by small protein conjugation
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
protein modification by small protein conjugation or removal
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II
positive regulation of developmental process
generation of neurons
positive regulation of transcription, DNA-templated
regulation of cell population proliferation
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of multicellular organismal process
regulation of cell differentiation
positive regulation of nucleobase-containing compound metabolic process