RNF111 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF111 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF111
  * **<color #00a2e8>Official Name</color>**: ring finger protein 111
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54778|54778]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZNA4|Q6ZNA4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF111&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF111|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-rbx1|
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SUMO polymer binding|
|ubiquitin-dependent SMAD protein catabolic process|
|global genome nucleotide-excision repair|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|SMAD binding|
|PML body|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|nucleotide-excision repair|
|regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of protein ubiquitination|
|regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of protein modification by small protein conjugation or removal|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of protein ubiquitination|
|ubiquitin protein ligase activity|
|regulation of protein modification by small protein conjugation or removal|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|protein polyubiquitination|
|pattern specification process|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|proteolysis|
|positive regulation of transcription, DNA-templated|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-3.06|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.08|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-2.07|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.87|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.79|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.75|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.72|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.73|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.76|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.8|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.85|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.86|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.15|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.22|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.29|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4102
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF111 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>