RNF111

Gene Information

Official Symbol: RNF111
Official Name: ring finger protein 111
Aliases and Previous Symbols: N/A
Entrez ID: 54778
UniProt: Q6ZNA4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 1μM R01 exp59	-3.06
Bortezomib 0.005μM R00 exp6	-2.08
WNT3A 44ng/ml R08 exp537	-2.07
Mubritinib 0.2μM R01 exp48	-1.87
Azithromycin 100μM R08 exp452	-1.79
HMS-I1 1μM R01 exp46	-1.75
Taxol 0.002μM R01 exp54	-1.72
Nifurtimox 1μM R03 exp141	1.73
TRAIL 5ng/ml R00 exp35	1.76
Erlotinib 10μM R05 exp216	1.8
Trametinib 10μM R02 exp83	1.85
Wortmannin 0.5μM R00 exp37	1.86
Rapamycin 0.001μM R08 exp429	2.15
Wiskostatin 3μM R07 exp422	2.22
Rapamycin 1μM R00 exp29	2.29
Vemurafenib 6.6μM R08 exp434	2.41

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4102
Expression level (log2 read counts): 5.67

Expression Distribution

zf-rbx1
zf-C3HC4

SUMO polymer binding
ubiquitin-dependent SMAD protein catabolic process
global genome nucleotide-excision repair
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cellular response to transforming growth factor beta stimulus
SMAD binding
PML body
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
nucleotide-excision repair
regulation of transforming growth factor beta receptor signaling pathway
positive regulation of protein ubiquitination
regulation of cellular response to transforming growth factor beta stimulus
positive regulation of protein modification by small protein conjugation or removal
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of protein ubiquitination
ubiquitin protein ligase activity
regulation of protein modification by small protein conjugation or removal
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
protein polyubiquitination
pattern specification process
DNA repair
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
protein-containing complex
cellular protein catabolic process
protein catabolic process
protein ubiquitination
enzyme linked receptor protein signaling pathway
DNA metabolic process
protein modification by small protein conjugation
cellular response to DNA damage stimulus
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
positive regulation of transcription by RNA polymerase II
positive regulation of protein modification process