RNF122

Entrez Summary: N/A
UniProt Summary: May induce necrosis and apoptosis. May play a role in cell viability. {ECO:0000269|PubMed:16751333}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-rbx1
zf-C3HC4

negative regulation of mitochondrial membrane potential
negative regulation of membrane potential
protein autoubiquitination
regulation of mitochondrial membrane potential
endomembrane system
ubiquitin protein ligase activity
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
regulation of membrane potential
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
positive regulation of apoptotic process
positive regulation of programmed cell death
protein catabolic process
protein ubiquitination
positive regulation of cell death
protein modification by small protein conjugation
cellular macromolecule catabolic process
Golgi apparatus
protein modification by small protein conjugation or removal
endoplasmic reticulum
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
organic substance catabolic process
cellular catabolic process