RNF135

Entrez Summary: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SPRY
zf-C3HC4

positive regulation of interferon-beta production
ribonucleoprotein complex binding
negative regulation of type I interferon production
regulation of interferon-beta production
positive regulation of type I interferon production
regulation of type I interferon production
ubiquitin-protein transferase activity
negative regulation of cytokine production
positive regulation of cytokine production
regulation of innate immune response
regulation of response to biotic stimulus
protein ubiquitination
regulation of cytokine production
regulation of defense response
innate immune response
protein modification by small protein conjugation
regulation of multi-organism process
defense response to other organism
protein modification by small protein conjugation or removal
identical protein binding
regulation of response to external stimulus
regulation of immune response
negative regulation of multicellular organismal process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
regulation of response to stress
regulation of immune system process
positive regulation of multicellular organismal process
immune response