RNF152

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937). {ECO:0000269|PubMed:21203937, ECO:0000269|PubMed:25936802}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

integral component of organelle membrane
negative regulation of TORC1 signaling
small GTPase binding
protein K63-linked ubiquitination
regulation of TORC1 signaling
cellular response to amino acid starvation
response to amino acid starvation
negative regulation of TOR signaling
protein K48-linked ubiquitination
regulation of TOR signaling
positive regulation of autophagy
cellular response to starvation
response to starvation
ubiquitin protein ligase activity
cellular response to nutrient levels
ubiquitin-protein transferase activity
lysosome
cellular response to extracellular stimulus
protein polyubiquitination
lysosomal membrane
regulation of autophagy
cellular response to external stimulus
positive regulation of cellular catabolic process
positive regulation of catabolic process
response to nutrient levels
negative regulation of intracellular signal transduction
response to extracellular stimulus
protein ubiquitination
protein modification by small protein conjugation
regulation of cellular catabolic process
apoptotic process
protein modification by small protein conjugation or removal
regulation of catabolic process
programmed cell death
cell death
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
cellular response to stress