RNF31 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF31 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF31
  * **<color #00a2e8>Official Name</color>**: ring finger protein 31
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55072|55072]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EP0|Q96EP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF31&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF31|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612487|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PUB|
|IBR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD40 signaling pathway|
|protein linear polyubiquitination|
|LUBAC complex|
|CD40 receptor complex|
|positive regulation of protein targeting to mitochondrion|
|regulation of protein targeting to mitochondrion|
|cytoplasmic side of plasma membrane|
|regulation of tumor necrosis factor-mediated signaling pathway|
|positive regulation of establishment of protein localization to mitochondrion|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of establishment of protein localization to mitochondrion|
|ubiquitin binding|
|regulation of protein targeting|
|positive regulation of mitochondrion organization|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of intracellular protein transport|
|regulation of cytokine-mediated signaling pathway|
|T cell receptor signaling pathway|
|regulation of response to cytokine stimulus|
|regulation of mitochondrion organization|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|ubiquitin-protein transferase activity|
|positive regulation of DNA-binding transcription factor activity|
|ubiquitin protein ligase binding|
|antigen receptor-mediated signaling pathway|
|protein polyubiquitination|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of establishment of protein localization|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of cellular protein localization|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|activation of immune response|
|protein ubiquitination|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|positive regulation of immune response|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-3.76|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9128
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF31 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>