RNF31

Gene Information

Official Symbol: RNF31
Official Name: ring finger protein 31
Aliases and Previous Symbols: N/A
Entrez ID: 55072
UniProt: Q96EP0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015].
UniProt Summary: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9128
Expression level (log2 read counts): 5.36

Expression Distribution

Screen	Score
TNF-alpha 44ng/ml R08 exp533	-3.76
Nicotinate 1000μM R03 exp140	1.8

PUB
IBR

CD40 signaling pathway
protein linear polyubiquitination
LUBAC complex
CD40 receptor complex
positive regulation of protein targeting to mitochondrion
regulation of protein targeting to mitochondrion
cytoplasmic side of plasma membrane
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of establishment of protein localization to mitochondrion
I-kappaB kinase/NF-kappaB signaling
regulation of establishment of protein localization to mitochondrion
ubiquitin binding
regulation of protein targeting
positive regulation of mitochondrion organization
positive regulation of NF-kappaB transcription factor activity
positive regulation of intracellular protein transport
regulation of cytokine-mediated signaling pathway
T cell receptor signaling pathway
regulation of response to cytokine stimulus
regulation of mitochondrion organization
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of intracellular transport
regulation of intracellular protein transport
regulation of I-kappaB kinase/NF-kappaB signaling
ubiquitin-protein transferase activity
positive regulation of DNA-binding transcription factor activity
ubiquitin protein ligase binding
antigen receptor-mediated signaling pathway
protein polyubiquitination
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
regulation of DNA-binding transcription factor activity
immune response-activating cell surface receptor signaling pathway
positive regulation of establishment of protein localization
immune response-regulating cell surface receptor signaling pathway
regulation of cellular protein localization
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of organelle organization