RNPS1 [The Human Chemical-Genetic Interaction Map Project]

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======= RNPS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNPS1
  * **<color #00a2e8>Official Name</color>**: RNA binding protein with serine rich domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10921|10921]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15287|Q15287]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNPS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNPS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606447|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ASAP complex|
|negative regulation of mRNA splicing, via spliceosome|
|exon-exon junction complex|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|regulation of alternative mRNA splicing, via spliceosome|
|mRNA 3-UTR binding|
|negative regulation of mRNA metabolic process|
|mRNA 3-end processing|
|regulation of mRNA splicing, via spliceosome|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|regulation of RNA splicing|
|regulation of mRNA processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|RNA localization|
|mRNA catabolic process|
|nucleobase-containing compound transport|
|RNA catabolic process|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|nuclear speck|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|mRNA metabolic process|
|positive regulation of cell death|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.35|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.24|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.16|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.77|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.75|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.72|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.72|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|1.74|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.74|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.9|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.91|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.92|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.02|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.03|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.33|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.44|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 370/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|17/28|
|bone|16/25|
|breast|20/33|
|central nervous system|30/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|7/15|
|kidney|9/21|
|liver|13/20|
|lung|37/75|
|lymphocyte|6/14|
|ovary|15/26|
|pancreas|13/24|
|peripheral nervous system|12/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|3/7|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|10/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3395
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNPS1 Expression in NALM6 Cells: 7.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>