ROGDI [The Human Chemical-Genetic Interaction Map Project]

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======= ROGDI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ROGDI
  * **<color #00a2e8>Official Name</color>**: rogdi atypical leucine zipper
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79641|79641]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZN7|Q9GZN7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ROGDI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ROGDI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614574|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a positive regulator of cell proliferation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rogdi lz|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RAVE complex|
|vacuolar acidification|
|intracellular pH reduction|
|pH reduction|
|presynaptic membrane|
|odontogenesis of dentin-containing tooth|
|regulation of intracellular pH|
|intracellular|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|synaptic vesicle|
|odontogenesis|
|perikaryon|
|monovalent inorganic cation homeostasis|
|nuclear envelope|
|axon|
|dendrite|
|cell junction|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|cellular cation homeostasis|
|cellular ion homeostasis|
|immune system development|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|central nervous system development|
|chemical homeostasis|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.589|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8501
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ROGDI Expression in NALM6 Cells: 2.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>