ROGDI

Entrez Summary: This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012].
UniProt Summary: May act as a positive regulator of cell proliferation. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RAVE complex
vacuolar acidification
intracellular pH reduction
pH reduction
presynaptic membrane
odontogenesis of dentin-containing tooth
regulation of intracellular pH
intracellular
regulation of cellular pH
regulation of pH
cellular monovalent inorganic cation homeostasis
synaptic vesicle
odontogenesis
perikaryon
monovalent inorganic cation homeostasis
nuclear envelope
axon
dendrite
cell junction
hemopoiesis
hematopoietic or lymphoid organ development
cellular cation homeostasis
cellular ion homeostasis
immune system development
cation homeostasis
inorganic ion homeostasis
brain development
cellular chemical homeostasis
head development
ion homeostasis
cellular homeostasis
positive regulation of cell population proliferation
animal organ morphogenesis
central nervous system development
chemical homeostasis
regulation of cell population proliferation
neurogenesis
homeostatic process