ROM1 [The Human Chemical-Genetic Interaction Map Project]

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======= ROM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ROM1
  * **<color #00a2e8>Official Name</color>**: retinal outer segment membrane protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6094|6094]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03395|Q03395]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ROM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ROM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180721|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tetraspannin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retina vasculature development in camera-type eye|
|photoreceptor outer segment membrane|
|camera-type eye photoreceptor cell differentiation|
|eye photoreceptor cell differentiation|
|retina morphogenesis in camera-type eye|
|photoreceptor cell differentiation|
|neural retina development|
|camera-type eye morphogenesis|
|retina development in camera-type eye|
|eye morphogenesis|
|visual perception|
|sensory perception of light stimulus|
|sensory organ morphogenesis|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|vasculature development|
|cardiovascular system development|
|sensory organ development|
|circulatory system development|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|sensory perception|
|neuron differentiation|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|neurogenesis|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7020
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ROM1 Expression in NALM6 Cells: -0.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>