ROM1
Gene Information
- Official Symbol: ROM1
- Official Name: retinal outer segment membrane protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6094
- UniProt: Q03395
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008].
- UniProt Summary: May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7020
- Expression level (log2 read counts): -0.02
ROM1 Expression in NALM6 Cells: -0.02
