ROMO1 [The Human Chemical-Genetic Interaction Map Project]

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======= ROMO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ROMO1
  * **<color #00a2e8>Official Name</color>**: reactive oxygen species modulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=140823|140823]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60602|P60602]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ROMO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ROMO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618894|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Romo1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|replicative cell aging|
|cytolysis in other organism|
|TIM23 mitochondrial import inner membrane translocase complex|
|protein insertion into mitochondrial inner membrane|
|establishment of protein localization to mitochondrial membrane|
|protein import into mitochondrial matrix|
|protein insertion into mitochondrial membrane|
|multi-organism cellular process|
|cytolysis|
|protein transmembrane import into intracellular organelle|
|protein insertion into membrane|
|inner mitochondrial membrane organization|
|intracellular protein transmembrane transport|
|killing of cells of other organism|
|disruption of cells of other organism|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|cell aging|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|defense response to Gram-negative bacterium|
|cell killing|
|mitochondrial transmembrane transport|
|defense response to Gram-positive bacterium|
|positive regulation of reactive oxygen species metabolic process|
|antimicrobial humoral response|
|mitochondrial membrane organization|
|cellular response to reactive oxygen species|
|protein import|
|modification of morphology or physiology of other organism|
|regulation of reactive oxygen species metabolic process|
|response to reactive oxygen species|
|mitochondrial transport|
|cellular response to oxidative stress|
|establishment of protein localization to membrane|
|aging|
|defense response to bacterium|
|humoral immune response|
|protein targeting|
|response to oxidative stress|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to membrane|
|response to bacterium|
|protein localization to organelle|
|molecular function|
|interspecies interaction between organisms|
|membrane organization|
|positive regulation of cell population proliferation|
|defense response to other organism|
|intracellular protein transport|
|cellular response to oxygen-containing compound|
|mitochondrion|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.79|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.78|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.74|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.71|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.72|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.75|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.75|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.76|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.76|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.76|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.81|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.83|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.83|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.9|
|[[:results:exp539|42°C R08 exp539]]|1.93|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.97|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.99|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.01|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.01|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.01|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.02|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.03|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.06|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.07|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.08|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.09|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.11|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.15|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.19|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.19|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.19|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.26|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.27|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.28|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.29|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.3|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.32|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.33|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.38|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.43|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.58|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.59|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.86|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.89|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.89|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.91|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.01|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.33|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.45|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.66|
|[[:results:exp135|MS023 7μM R03 exp135]]|4.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:crls1|CRLS1]]|0.712|
|[[:human genes:t:triap1|TRIAP1]]|0.7|
|[[:human genes:p:pmm2|PMM2]]|0.635|
|[[:human genes:t:taz|TAZ]]|0.633|
|[[:human genes:d:dohh|DOHH]]|0.631|
|[[:human genes:d:dnlz|DNLZ]]|0.63|
|[[:human genes:o:opa1|OPA1]]|0.621|
|[[:human genes:t:thg1l|THG1L]]|0.601|
|[[:human genes:d:dpagt1|DPAGT1]]|0.594|
|[[:human genes:t:tamm41|TAMM41]]|0.59|
|[[:human genes:u:uap1|UAP1]]|0.583|
|[[:human genes:r:rpe|RPE]]|0.581|
|[[:human genes:s:slc25a26|SLC25A26]]|0.581|
|[[:human genes:a:alg1|ALG1]]|0.574|
|[[:human genes:t:timm13|TIMM13]]|0.566|
|[[:human genes:s:srp14|SRP14]]|0.564|
|[[:human genes:u:ube2g2|UBE2G2]]|0.563|
|[[:human genes:b:bak1|BAK1]]|0.563|
|[[:human genes:a:apaf1|APAF1]]|0.561|
|[[:human genes:h:hccs|HCCS]]|0.557|
|[[:human genes:k:kdsr|KDSR]]|0.557|
|[[:human genes:c:casp9|CASP9]]|0.55|
|[[:human genes:p:plaa|PLAA]]|0.549|
|[[:human genes:v:vdac2|VDAC2]]|0.547|
|[[:human genes:p:pgm3|PGM3]]|0.53|
|[[:human genes:s:serf2|SERF2]]|0.529|
|[[:human genes:r:rptor|RPTOR]]|0.528|
|[[:human genes:s:sec62|SEC62]]|0.527|
|[[:human genes:a:atp5a1|ATP5A1]]|0.526|
|[[:human genes:a:atp5o|ATP5O]]|0.523|
|[[:human genes:t:trmt10a|TRMT10A]]|0.521|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.52|
|[[:human genes:m:mbtps2|MBTPS2]]|0.517|
|[[:human genes:d:dhrsx|DHRSX]]|0.51|
|[[:human genes:r:rpia|RPIA]]|0.507|
|[[:human genes:p:parl|PARL]]|0.507|
|[[:human genes:f:faf2|FAF2]]|0.504|
|[[:human genes:t:trmt61a|TRMT61A]]|0.504|
|[[:human genes:m:mlst8|MLST8]]|0.503|
|[[:human genes:s:srd5a3|SRD5A3]]|0.503|
|[[:human genes:a:atxn10|ATXN10]]|0.503|
|[[:human genes:a:atp2a2|ATP2A2]]|0.502|
|[[:human genes:p:ppcs|PPCS]]|0.496|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.493|
|[[:human genes:a:alg5|ALG5]]|0.491|
|[[:human genes:c:cycs|CYCS]]|0.491|
|[[:human genes:a:alg6|ALG6]]|0.49|
|[[:human genes:p:pdpk1|PDPK1]]|0.486|
|[[:human genes:g:gfpt1|GFPT1]]|0.485|
|[[:human genes:k:kctd5|KCTD5]]|0.485|
|[[:human genes:t:trnt1|TRNT1]]|0.484|
|[[:human genes:u:uhrf1|UHRF1]]|0.48|
|[[:human genes:t:tkt|TKT]]|0.478|
|[[:human genes:v:vezt|VEZT]]|0.478|
|[[:human genes:n:nsd1|NSD1]]|0.475|
|[[:human genes:c:cept1|CEPT1]]|0.474|
|[[:human genes:m:march5|MARCH5]]|0.473|
|[[:human genes:p:pgs1|PGS1]]|0.471|
|[[:human genes:b:bap1|BAP1]]|0.471|
|[[:human genes:m:mbtps1|MBTPS1]]|0.468|
|[[:human genes:w:wdr24|WDR24]]|0.468|
|[[:human genes:h:hspd1|HSPD1]]|0.467|
|[[:human genes:s:sec63|SEC63]]|0.466|
|[[:human genes:u:ubqln1|UBQLN1]]|0.466|
|[[:human genes:o:oraov1|ORAOV1]]|0.466|
|[[:human genes:a:atp5b|ATP5B]]|0.465|
|[[:human genes:m:mrps6|MRPS6]]|0.462|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.462|
|[[:human genes:m:mrps34|MRPS34]]|0.46|
|[[:human genes:p:pdss1|PDSS1]]|0.46|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.459|
|[[:human genes:e:exoc4|EXOC4]]|0.458|
|[[:human genes:m:metap2|METAP2]]|0.457|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.457|
|[[:human genes:p:pgls|PGLS]]|0.456|
|[[:human genes:b:bptf|BPTF]]|0.455|
|[[:human genes:e:eny2|ENY2]]|0.455|
|[[:human genes:a:atp5d|ATP5D]]|0.453|
|[[:human genes:a:alg13|ALG13]]|0.452|
|[[:human genes:d:dad1|DAD1]]|0.452|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.452|
|[[:human genes:p:pam16|PAM16]]|0.451|
|[[:human genes:r:rnmt|RNMT]]|0.449|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.449|
|[[:human genes:s:ssb|SSB]]|0.447|
|[[:human genes:m:mrpl21|MRPL21]]|0.447|
|[[:human genes:d:dolk|DOLK]]|0.446|
|[[:human genes:u:utp23|UTP23]]|0.446|
|[[:human genes:c:cbfb|CBFB]]|0.445|
|[[:human genes:p:ppa2|PPA2]]|0.445|
|[[:human genes:r:rpusd4|RPUSD4]]|0.445|
|[[:human genes:r:rpn1|RPN1]]|0.444|
|[[:human genes:t:tmem41b|TMEM41B]]|0.444|
|[[:human genes:c:coq3|COQ3]]|0.443|
|[[:human genes:y:yars2|YARS2]]|0.443|
|[[:human genes:m:mfn1|MFN1]]|0.442|
|[[:human genes:m:mrps18a|MRPS18A]]|0.441|
|[[:human genes:f:fh|FH]]|0.441|
|[[:human genes:u:ube2m|UBE2M]]|0.441|
|[[:human genes:p:pisd|PISD]]|0.44|
|[[:human genes:a:atic|ATIC]]|0.44|
|[[:human genes:m:mrps14|MRPS14]]|0.439|
|[[:human genes:d:dhps|DHPS]]|0.439|
|[[:human genes:p:pars2|PARS2]]|0.438|
|[[:human genes:s:sec61g|SEC61G]]|0.438|
|[[:human genes:a:alg2|ALG2]]|0.437|
|[[:human genes:z:zzz3|ZZZ3]]|0.437|
|[[:human genes:l:lonp1|LONP1]]|0.436|
|[[:human genes:e:elp3|ELP3]]|0.436|
|[[:human genes:m:mrpl23|MRPL23]]|0.433|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.432|
|[[:human genes:l:lsm10|LSM10]]|0.432|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.431|
|[[:human genes:d:dap3|DAP3]]|0.429|
|[[:human genes:t:ttc4|TTC4]]|0.429|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.429|
|[[:human genes:b:bcs1l|BCS1L]]|0.428|
|[[:human genes:u:ube2j1|UBE2J1]]|0.428|
|[[:human genes:a:atp5j|ATP5J]]|0.427|
|[[:human genes:d:dars2|DARS2]]|0.427|
|[[:human genes:p:ptdss1|PTDSS1]]|0.426|
|[[:human genes:a:atad1|ATAD1]]|0.425|
|[[:human genes:r:rtcb|RTCB]]|0.423|
|[[:human genes:p:pdap1|PDAP1]]|0.421|
|[[:human genes:t:tpi1|TPI1]]|0.421|
|[[:human genes:e:eno1|ENO1]]|0.42|
|[[:human genes:t:trim28|TRIM28]]|0.418|
|[[:human genes:c:cd81|CD81]]|0.417|
|[[:human genes:m:mrps16|MRPS16]]|0.415|
|[[:human genes:d:ddost|DDOST]]|0.415|
|[[:human genes:p:pelo|PELO]]|0.415|
|[[:human genes:n:nae1|NAE1]]|0.414|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.414|
|[[:human genes:s:sec61b|SEC61B]]|0.412|
|[[:human genes:r:rabif|RABIF]]|0.412|
|[[:human genes:d:dr1|DR1]]|0.412|
|[[:human genes:o:ost4|OST4]]|0.411|
|[[:human genes:g:gmppb|GMPPB]]|0.411|
|[[:human genes:b:brwd1|BRWD1]]|0.409|
|[[:human genes:c:chchd4|CHCHD4]]|0.408|
|[[:human genes:a:alg8|ALG8]]|0.408|
|[[:human genes:a:atp5h|ATP5H]]|0.408|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.407|
|[[:human genes:s:slc25a20|SLC25A20]]|0.407|
|[[:human genes:p:pnpt1|PNPT1]]|0.407|
|[[:human genes:t:trmt5|TRMT5]]|0.407|
|[[:human genes:f:fech|FECH]]|0.406|
|[[:human genes:c:coq6|COQ6]]|0.405|
|[[:human genes:m:mrpl47|MRPL47]]|0.404|
|[[:human genes:m:mtor|MTOR]]|0.404|
|[[:human genes:t:thoc6|THOC6]]|0.404|
|[[:human genes:a:adsl|ADSL]]|0.403|
|[[:human genes:r:rbfa|RBFA]]|0.403|
|[[:human genes:d:diablo|DIABLO]]|0.403|
|[[:human genes:t:timm8b|TIMM8B]]|0.402|
|[[:human genes:t:txnl4b|TXNL4B]]|0.402|
|[[:human genes:g:gpi|GPI]]|0.402|
|[[:human genes:s:slmo2|SLMO2]]|0.401|
|[[:human genes:t:timm44|TIMM44]]|0.401|
|[[:human genes:g:gemin6|GEMIN6]]|0.4|
|[[:human genes:c:cep57|CEP57]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 559/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|24/28|
|bone|18/26|
|breast|28/33|
|central nervous system|39/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|14/21|
|liver|16/20|
|lung|55/75|
|lymphocyte|13/16|
|ovary|19/26|
|pancreas|18/24|
|peripheral nervous system|10/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|23/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 61
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ROMO1 Expression in NALM6 Cells: 4.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>