ROMO1

Gene Information

Official Symbol: ROMO1
Official Name: reactive oxygen species modulator 1
Aliases and Previous Symbols: N/A
Entrez ID: 140823
UniProt: P60602
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PNU96415E 10μM R03 exp145	-1.79
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.78
UM0011500 5μM R05 exp245	-1.74
GSK-J4 1.5μM R08 exp441	1.71
SNS-032 15μM R08 exp443	1.72
Nocodazole 0.2μM R02 exp64	1.75
Salinomycin 3.5μM R08 exp521	1.75
Ammonium tetrathiomolybdate 10μM R08 exp448	1.76
Aphidicolin 0.4μM R08 exp440	1.76
KU-0063794 3.8μM R02 exp71	1.76
ONC212 0.15μM R08 exp513	1.81
ML-792 0.2μM R08 exp505	1.83
MS023 2μM R03 exp134	1.83
Etoposide 0.1μM R05 exp198	1.9
42°C R08 exp539	1.93
Nocodazole 0.1μM R03 exp94	1.97
AICAR 240μM R03 exp116	1.99
Etoposide 0.3μM R05 exp199	2
Hinokiflavone 12μM R08 exp487	2
INK128 0.2μM R02 exp70	2
LLY-283 2.6μM R06 exp290	2.01
Rotenone 20μM R00 exp34	2.01
VER-155008 3.9μM R06 exp301	2.01
RO-3307 4.7μM R02 exp80	2.02
MLN-4924 0.2μM R00 exp21	2.03
Olaparib 4μM R08 exp512	2.06
BML-284 0.09μM R08 exp460	2.07
AICAR 240μM R05 exp211	2.08
CR131-b 0.005μM R08 exp474	2.09
GSK626616 14μM R08 exp485	2.11
Thimerosal 0.85μM R08 exp529	2.15
Dorsomorphin 5μM R07 exp357	2.19
R-DABN 8μM R03 exp111	2.19
Sulforaphane 9μM R08 exp526 no dilution day6	2.19
Arsenate 40μM R06 exp264	2.26
BI-D1870 3.15μM R02 exp66	2.27
BI-6727 0.04μM R03 exp98	2.28
BI-2536 0.02μM R03 exp96	2.29
Milciclib 2μM R08 exp502	2.3
Vinblastine 0.2μM R03 exp108	2.32
Erlotinib 10μM R05 exp216	2.33
5-Azacytidine 2μM R07 exp330	2.38
Benzoate 20000μM R08 exp456	2.43
CB-5083 0.4μM R08 exp468	2.58
Bleomycin 5μM R08 exp459	2.59
GSK461364A 0.1μM R03 exp126	2.86
Doxorubicin 0.02μM R08 exp478	2.89
Staurosporine 0.02μM R08 exp524	2.89
DABN racemic mixture R03 exp93	2.91
Mitomycin-C 0.06μM R08 exp503	3.01
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.33
UM131593 0.2μM R03 exp106	3.45
Hippuristanol 0.12μM R08 exp488	3.66
MS023 7μM R03 exp135	4.49

Gene	Correlation
CRLS1	0.712
TRIAP1	0.7
PMM2	0.635
TAZ	0.633
DOHH	0.631
DNLZ	0.63
OPA1	0.621
THG1L	0.601
DPAGT1	0.594
TAMM41	0.59
UAP1	0.583
RPE	0.581
SLC25A26	0.581
ALG1	0.574
TIMM13	0.566
SRP14	0.564
UBE2G2	0.563
BAK1	0.563
APAF1	0.561
HCCS	0.557
KDSR	0.557
CASP9	0.55
PLAA	0.549
VDAC2	0.547
PGM3	0.53
SERF2	0.529
RPTOR	0.528
SEC62	0.527
ATP5A1	0.526
ATP5O	0.523
TRMT10A	0.521
SUPV3L1	0.52
MBTPS2	0.517
DHRSX	0.51
RPIA	0.507
PARL	0.507
FAF2	0.504
TRMT61A	0.504
MLST8	0.503
SRD5A3	0.503
ATXN10	0.503
ATP2A2	0.502
PPCS	0.496
AASDHPPT	0.493
ALG5	0.491
CYCS	0.491
ALG6	0.49
PDPK1	0.486
GFPT1	0.485
KCTD5	0.485
TRNT1	0.484
UHRF1	0.48
TKT	0.478
VEZT	0.478
NSD1	0.475
CEPT1	0.474
MARCH5	0.473
PGS1	0.471
BAP1	0.471
MBTPS1	0.468
WDR24	0.468
HSPD1	0.467
SEC63	0.466
UBQLN1	0.466
ORAOV1	0.466
ATP5B	0.465
MRPS6	0.462
GTF3C6	0.462
MRPS34	0.46
PDSS1	0.46
CTDNEP1	0.459
EXOC4	0.458
METAP2	0.457
KIAA0391	0.457
PGLS	0.456
BPTF	0.455
ENY2	0.455
ATP5D	0.453
ALG13	0.452
DAD1	0.452
GTF3C4	0.452
PAM16	0.451
RNMT	0.449
PTPMT1	0.449
SSB	0.447
MRPL21	0.447
DOLK	0.446
UTP23	0.446
CBFB	0.445
PPA2	0.445
RPUSD4	0.445
RPN1	0.444
TMEM41B	0.444
COQ3	0.443
YARS2	0.443
MFN1	0.442
MRPS18A	0.441
FH	0.441
UBE2M	0.441
PISD	0.44
ATIC	0.44
MRPS14	0.439
DHPS	0.439
PARS2	0.438
SEC61G	0.438
ALG2	0.437
ZZZ3	0.437
LONP1	0.436
ELP3	0.436
MRPL23	0.433
MAPKAP1	0.432
LSM10	0.432
LAMTOR4	0.431
DAP3	0.429
TTC4	0.429
PPP2R3C	0.429
BCS1L	0.428
UBE2J1	0.428
ATP5J	0.427
DARS2	0.427
PTDSS1	0.426
ATAD1	0.425
RTCB	0.423
PDAP1	0.421
TPI1	0.421
ENO1	0.42
TRIM28	0.418
CD81	0.417
MRPS16	0.415
DDOST	0.415
PELO	0.415
NAE1	0.414
GTF3C3	0.414
SEC61B	0.412
RABIF	0.412
DR1	0.412
OST4	0.411
GMPPB	0.411
BRWD1	0.409
CHCHD4	0.408
ALG8	0.408
ATP5H	0.408
IRF2BP2	0.407
SLC25A20	0.407
PNPT1	0.407
TRMT5	0.407
FECH	0.406
COQ6	0.405
MRPL47	0.404
MTOR	0.404
THOC6	0.404
ADSL	0.403
RBFA	0.403
DIABLO	0.403
TIMM8B	0.402
TXNL4B	0.402
GPI	0.402
SLMO2	0.401
TIMM44	0.401
GEMIN6	0.4
CEP57	0.4

Global Fraction of Cell Lines Where Essential: 559/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	22/28
blood	24/28
bone	18/26
breast	28/33
central nervous system	39/56
cervix	2/4
colorectal	12/17
esophagus	12/13
fibroblast	1/1
gastric	11/16
kidney	14/21
liver	16/20
lung	55/75
lymphocyte	13/16
ovary	19/26
pancreas	18/24
peripheral nervous system	10/16
plasma cell	11/15
prostate	1/1
skin	22/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	21/22
urinary tract	23/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 61
Expression level (log2 read counts): 4.23

Expression Distribution

replicative cell aging
cytolysis in other organism
TIM23 mitochondrial import inner membrane translocase complex
protein insertion into mitochondrial inner membrane
establishment of protein localization to mitochondrial membrane
protein import into mitochondrial matrix
protein insertion into mitochondrial membrane
multi-organism cellular process
cytolysis
protein transmembrane import into intracellular organelle
protein insertion into membrane
inner mitochondrial membrane organization
intracellular protein transmembrane transport
killing of cells of other organism
disruption of cells of other organism
protein targeting to mitochondrion
protein transmembrane transport
cell aging
antimicrobial humoral immune response mediated by antimicrobial peptide
establishment of protein localization to mitochondrion
protein localization to mitochondrion
defense response to Gram-negative bacterium
cell killing
mitochondrial transmembrane transport
defense response to Gram-positive bacterium
positive regulation of reactive oxygen species metabolic process
antimicrobial humoral response
mitochondrial membrane organization
cellular response to reactive oxygen species
protein import
modification of morphology or physiology of other organism
regulation of reactive oxygen species metabolic process
response to reactive oxygen species
mitochondrial transport
cellular response to oxidative stress
establishment of protein localization to membrane
aging
defense response to bacterium
humoral immune response
protein targeting