ROR1 [The Human Chemical-Genetic Interaction Map Project]

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======= ROR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ROR1
  * **<color #00a2e8>Official Name</color>**: receptor tyrosine kinase like orphan receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4919|4919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01973|Q01973]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ROR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ROR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602336|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). {ECO:0000269|PubMed:25029443, ECO:0000269|PubMed:27162350}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kringle|
|ig|
|Pkinase Tyr|
|V-set|
|Pkinase|
|I-set|
|Fz|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|
|Wnt-activated receptor activity|
|astrocyte development|
|Wnt-protein binding|
|axon terminus|
|astrocyte differentiation|
|transmembrane receptor protein tyrosine kinase activity|
|stress fiber|
|Wnt signaling pathway, planar cell polarity pathway|
|glial cell development|
|regulation of establishment of planar polarity|
|non-canonical Wnt signaling pathway|
|peptidyl-tyrosine phosphorylation|
|sensory perception of sound|
|peptidyl-tyrosine modification|
|positive regulation of NF-kappaB transcription factor activity|
|sensory perception of mechanical stimulus|
|glial cell differentiation|
|regulation of morphogenesis of an epithelium|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|inner ear development|
|receptor complex|
|gliogenesis|
|ear development|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of animal organ morphogenesis|
|positive regulation of DNA-binding transcription factor activity|
|axon|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of DNA-binding transcription factor activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|sensory organ development|
|cell surface|
|enzyme linked receptor protein signaling pathway|
|peptidyl-amino acid modification|
|sensory perception|
|protein phosphorylation|
|central nervous system development|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|phosphorylation|
|nervous system process|
|integral component of plasma membrane|
|ATP binding|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6311
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.94 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ROR1 Expression in NALM6 Cells: 1.94'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>