ROR1

Entrez Summary: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012].
UniProt Summary: Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). {ECO:0000269|PubMed:25029443, ECO:0000269|PubMed:27162350}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
Wnt-activated receptor activity
astrocyte development
Wnt-protein binding
axon terminus
astrocyte differentiation
transmembrane receptor protein tyrosine kinase activity
stress fiber
Wnt signaling pathway, planar cell polarity pathway
glial cell development
regulation of establishment of planar polarity
non-canonical Wnt signaling pathway
peptidyl-tyrosine phosphorylation
sensory perception of sound
peptidyl-tyrosine modification
positive regulation of NF-kappaB transcription factor activity
sensory perception of mechanical stimulus
glial cell differentiation
regulation of morphogenesis of an epithelium
positive regulation of I-kappaB kinase/NF-kappaB signaling
inner ear development
receptor complex
gliogenesis
ear development
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of animal organ morphogenesis
positive regulation of DNA-binding transcription factor activity
axon
cell-cell signaling by wnt
Wnt signaling pathway
regulation of DNA-binding transcription factor activity
cell surface receptor signaling pathway involved in cell-cell signaling
transmembrane receptor protein tyrosine kinase signaling pathway
sensory organ development
cell surface
enzyme linked receptor protein signaling pathway
peptidyl-amino acid modification
sensory perception
protein phosphorylation
central nervous system development